|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
MKI67
|
|
gptkbp:antibodyUsed
|
MIB-1
|
|
gptkbp:assesses
|
cell proliferation
tumor growth
|
|
gptkbp:compatibleWith
|
quiescent cells
|
|
gptkbp:degradedDuring
|
end of mitosis
|
|
gptkbp:diagnosedBy
|
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
brain tumors
neuroendocrine tumors
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
MKI67 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000148773
|
|
gptkbp:expressedIn
|
proliferating cells
active phases of cell cycle
|
|
gptkbp:foundIn
|
gptkb:nucleus
|
|
gptkbp:function
|
cell proliferation marker
|
|
gptkbp:HGNC_ID
|
7102
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ki-67
|
|
gptkbp:locale
|
nucleolus
chromosome periphery
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q26
|
|
gptkbp:molecularWeight
|
~345 kDa
|
|
gptkbp:namedFor
|
Gerdes et al.
|
|
gptkbp:notExpressedDuring
|
resting phase (G0)
|
|
gptkbp:OMIM
|
176741
|
|
gptkbp:phosphorylatedDuring
|
mitosis
|
|
gptkbp:role
|
cell cycle regulation
chromosome organization
ribosomal RNA synthesis
|
|
gptkbp:significance
|
prognostic marker in cancer
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:subcellularLocation
|
nuclear
chromosome surface during mitosis
|
|
gptkbp:UniProtID
|
P46013
|
|
gptkbp:usedAs
|
proliferation index
|
|
gptkbp:usedIn
|
immunohistochemistry
|
|
gptkbp:usedInResearchOn
|
cell proliferation
cancer biology
cell cycle
|
|
gptkbp:usedToGuide
|
cancer treatment decisions
|
|
gptkbp:bfsParent
|
gptkb:topoisomerase_II_alpha
gptkb:HER2-positive_breast_cancer
|
|
gptkbp:bfsLayer
|
7
|