Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
passage of one DNA duplex through another
|
| gptkbp:EC_number |
5.99.1.3
|
| gptkbp:example |
gptkb:topoisomerase_II_alpha
gptkb:DNA_gyrase topoisomerase II beta topoisomerase IV |
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
alters DNA topology
introduces double-strand breaks in DNA removes DNA supercoils untangles DNA |
| gptkbp:gene |
TOP2A
TOP2B |
| https://www.w3.org/2000/01/rdf-schema#label |
Type II topoisomerase
|
| gptkbp:inhibitedBy |
antineoplastic agents
|
| gptkbp:mechanismOfAction |
breaks and rejoins DNA strands
|
| gptkbp:requires |
gptkb:ATP
|
| gptkbp:role |
DNA replication
transcription regulation chromosome segregation |
| gptkbp:subunit |
multimeric protein
|
| gptkbp:target |
gptkb:doxorubicin
antineoplastic agent quinolone antibiotics |
| gptkbp:bfsParent |
gptkb:enzyme
|
| gptkbp:bfsLayer |
5
|