sialic acid-binding immunoglobulin-like lectins (Siglecs)
GPTKB entity
Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Siglecs
|
| gptkbp:binds |
sialic acid
|
| gptkbp:contains |
immunoglobulin-like domains
|
| gptkbp:cytoplasmicTailContains |
ITIM motifs
|
| gptkbp:evolvesFrom |
vertebrates
|
| gptkbp:expressedIn |
gptkb:B_cells
gptkb:T_cells gptkb:eosinophils gptkb:microglia dendritic cells macrophages immune cells monocytes neutrophils |
| gptkbp:firstDescribed |
1998
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
immune regulation
cell-cell interaction |
| https://www.w3.org/2000/01/rdf-schema#label |
sialic acid-binding immunoglobulin-like lectins (Siglecs)
|
| gptkbp:includes |
gptkb:Siglec-8
gptkb:Siglec-2 gptkb:Siglec-3 gptkb:Siglec-4 gptkb:Siglec-6 gptkb:Siglec-7 gptkb:Siglec-9 Siglec-1 Siglec-10 Siglec-11 Siglec-12 Siglec-14 Siglec-15 Siglec-5 |
| gptkbp:involvedIn |
infectious diseases
autoimmunity cancer immunology self-nonself discrimination |
| gptkbp:locale |
cell surface
|
| gptkbp:memberOf |
gptkb:immunoglobulin_superfamily
|
| gptkbp:modulatedBy |
immune cell signaling
|
| gptkbp:proteinFamily |
SIGLEC genes
|
| gptkbp:recognizedBy |
glycans containing sialic acid
|
| gptkbp:regulates |
apoptosis
phagocytosis inflammatory response cytokine production |
| gptkbp:structure |
cytoplasmic tail
transmembrane region extracellular immunoglobulin-like domains |
| gptkbp:target |
therapeutic antibodies
|
| gptkbp:bfsParent |
gptkb:CD33
|
| gptkbp:bfsLayer |
7
|