Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alternativeName |
SIGLEC8
Sialic acid-binding Ig-like lectin 8 |
| gptkbp:biologicalProcess |
immune response regulation
|
| gptkbp:cellularComponent |
gptkb:cell_membrane
|
| gptkbp:discoveredBy |
2001
|
| gptkbp:encodedBy |
SIGLEC8 gene
|
| gptkbp:Entrez_Gene_ID |
27180
|
| gptkbp:expressedIn |
gptkb:basophils
gptkb:mast_cells gptkb:eosinophils |
| gptkbp:foundIn |
humans
|
| gptkbp:function |
induces apoptosis in eosinophils
inhibits mast cell activation |
| gptkbp:HGNC_ID |
gptkb:HGNC:10874
|
| https://www.w3.org/2000/01/rdf-schema#label |
Siglec-8
|
| gptkbp:ligand |
sialylated glycans
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19q13.4
|
| gptkbp:memberOf |
gptkb:immunoglobulin_superfamily
gptkb:Siglec_family |
| gptkbp:OMIM |
606664
|
| gptkbp:structure |
contains immunoglobulin-like domains
|
| gptkbp:target |
therapeutic antibodies in eosinophilic diseases
|
| gptkbp:UniProtID |
Q9NYZ4
|
| gptkbp:bfsParent |
gptkb:eosinophils
|
| gptkbp:bfsLayer |
7
|