Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:serpins
|
| gptkbp:example |
gptkb:plasminogen_activator_inhibitor-1
gptkb:alpha-1_antitrypsin gptkb:antithrombin gptkb:neuroserpin gptkb:C1-inhibitor ovalbumin serpinA1 serpinB1 serpinC1 serpinD1 serpinE1 |
| gptkbp:foundIn |
animals
plants microorganisms |
| gptkbp:function |
inhibit serine proteases
|
| https://www.w3.org/2000/01/rdf-schema#label |
serine protease inhibitors
|
| gptkbp:inhibitedBy |
gptkb:elastase
gptkb:tissue_plasminogen_activator gptkb:urokinase gptkb:thrombin gptkb:trypsin chymotrypsin plasmin |
| gptkbp:mechanismOfAction |
form covalent complex with target protease
|
| gptkbp:medicalUse |
treatment of stroke
treatment of deep vein thrombosis treatment of pulmonary embolism treatment of autoimmune diseases treatment of cancer treatment of inflammatory diseases treatment of hemophilia treatment of myocardial infarction treatment of liver disease treatment of hereditary angioedema treatment of neurodegenerative diseases treatment of clotting disorders treatment of emphysema treatment of lung disease treatment of sepsis treatment of thrombosis |
| gptkbp:mutationAssociatedWith |
gptkb:hereditary_hemorrhagic_telangiectasia
gptkb:alpha-1_antitrypsin_deficiency |
| gptkbp:proteinFamily |
SERPIN
|
| gptkbp:regulates |
inflammation
immune response blood coagulation |
| gptkbp:structure |
conserved serpin fold
|
| gptkbp:bfsParent |
gptkb:Chymotrypsin
gptkb:serpins gptkb:enteropeptidase |
| gptkbp:bfsLayer |
7
|