|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:trypsin
proteolytic cleavage of chymotrypsinogen
|
|
gptkbp:activeSiteResidue
|
Asp102
His57
Ser195
|
|
gptkbp:CASNumber
|
gptkb:9004-07-3
|
|
gptkbp:cleavage
|
aromatic amino acids (phenylalanine, tryptophan, tyrosine)
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:discoveredBy
|
gptkb:Moses_Kunitz
|
|
gptkbp:discoveredIn
|
1930s
|
|
gptkbp:EC_number
|
3.4.21.1
|
|
gptkbp:enzymeClassification
|
gptkb:serine_protease
|
|
gptkbp:foundIn
|
gptkb:small_intestine
pancreas
|
|
gptkbp:function
|
catalyzes hydrolysis of peptide bonds
|
|
gptkbp:gene
|
gptkb:CTRB
gptkb:CTRB1
gptkb:CTRB2
gptkb:CTRC
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Chymotrypsin
|
|
gptkbp:inhibitedBy
|
gptkb:aprotinin
gptkb:phenylmethylsulfonyl_fluoride_(PMSF)
gptkb:serine_protease_inhibitors
gptkb:soybean_trypsin_inhibitor
|
|
gptkbp:location
|
lumen of small intestine
|
|
gptkbp:medicalUse
|
digestive aid
anti-inflammatory agent
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:optimum_pH
|
7.8
|
|
gptkbp:optimumTemperature
|
37°C
|
|
gptkbp:PDB
|
gptkb:1GCT
|
|
gptkbp:predecessor
|
gptkb:chymotrypsinogen
|
|
gptkbp:producedBy
|
gptkb:pancreatic_acinar_cells
|
|
gptkbp:relatedTo
|
gptkb:elastase
gptkb:trypsin
|
|
gptkbp:roleInDigestion
|
protein digestion
|
|
gptkbp:significance
|
deficiency can cause digestive problems
|
|
gptkbp:species
|
gptkb:Bos_taurus
gptkb:Homo_sapiens
gptkb:Sus_scrofa
|
|
gptkbp:structure
|
contains catalytic triad (Ser195, His57, Asp102)
|
|
gptkbp:substrate
|
cleaves peptide bonds on the carboxyl side of aromatic amino acids
|
|
gptkbp:subunit
|
single polypeptide chain
|
|
gptkbp:UniProtID
|
gptkb:P00766
|
|
gptkbp:usedIn
|
protein sequencing
biochemical research
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|