|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activated_from
|
trypsinogen
|
|
gptkbp:activatedBy
|
gptkb:enteropeptidase
|
|
gptkbp:activeIn
|
gptkb:small_intestine
|
|
gptkbp:CASNumber
|
9002-07-7
|
|
gptkbp:catalyzes
|
hydrolysis of peptide bonds
|
|
gptkbp:cleaves_after
|
arginine
lysine
|
|
gptkbp:cofactor
|
gptkb:calcium_ion
|
|
gptkbp:discoveredBy
|
gptkb:Wilhelm_Kühne
|
|
gptkbp:discoveredIn
|
1876
|
|
gptkbp:EC_number
|
3.4.21.4
|
|
gptkbp:foundIn
|
pancreas
|
|
gptkbp:function
|
gptkb:serine_protease
|
|
gptkbp:gene
|
gptkb:PRSS1
gptkb:PRSS2
gptkb:PRSS3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
trypsin
|
|
gptkbp:inhibitedBy
|
gptkb:aprotinin
gptkb:soybean_trypsin_inhibitor
gptkb:alpha-1-antitrypsin
gptkb:trypsin_inhibitor
|
|
gptkbp:medicalUse
|
treatment of inflammation
debridement of wounds
|
|
gptkbp:molecularWeight
|
~24 kDa
|
|
gptkbp:optimum_pH
|
7.5-8.5
|
|
gptkbp:PDB
|
gptkb:1TRN
|
|
gptkbp:produced_as
|
trypsinogen
|
|
gptkbp:producedBy
|
gptkb:acinar_cells
|
|
gptkbp:related_enzyme
|
gptkb:elastase
gptkb:thrombin
chymotrypsin
|
|
gptkbp:role
|
pancreatitis
cystic fibrosis
hereditary trypsinogen deficiency
|
|
gptkbp:species
|
gptkb:Bos_taurus
gptkb:Homo_sapiens
gptkb:Sus_scrofa
|
|
gptkbp:structure
|
single polypeptide chain
|
|
gptkbp:substrate
|
proteins
|
|
gptkbp:UniProtID
|
gptkb:P00760
|
|
gptkbp:used_in
|
gptkb:biotechnology
mass spectrometry
proteomics
cell culture
protein digestion
peptide mapping
|
|
gptkbp:bfsParent
|
gptkb:enzyme
|
|
gptkbp:bfsLayer
|
5
|