antithrombin

URI: https://gptkb.org/entity/antithrombin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:serine_protease
gptkbp:activatedBy	gptkb:heparin
gptkbp:alternativeName	gptkb:ATIII gptkb:SERPINC1 gptkb:antithrombin_III
gptkbp:category	acute phase protein coagulation inhibitor
gptkbp:deficiencyCauses	gptkb:thrombophilia
gptkbp:discoveredBy	gptkb:Armand_J._Quick
gptkbp:encodedBy	gptkb:SERPINC1_gene
gptkbp:foundIn	blood plasma
gptkbp:function	gptkb:anticoagulant
gptkbp:halfLife	2.4 days
gptkbp:inhibitedBy	gptkb:factor_IXa gptkb:factor_Xa gptkb:thrombin gptkb:factor_XIIa gptkb:factor_XIa
gptkbp:length	432 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_1q25.1
gptkbp:medicalUse	gptkb:antithrombin_concentrate
gptkbp:molecularWeight	58 kDa
gptkbp:mutationAssociatedWith	gptkb:hereditary_antithrombin_deficiency
gptkbp:OMIM	107300
gptkbp:PDB	2ANT
gptkbp:presentIn	vertebrates
gptkbp:producedBy	liver
gptkbp:structureType	gptkb:protein
gptkbp:UniProtID	P01008
gptkbp:bfsParent	gptkb:Factor_X
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	antithrombin