|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:protease-activated_receptor_1_(PAR1)
gptkb:protease-activated_receptor_4_(PAR4)
platelets
factor V
factor VIII
factor XIII
protein C
thrombomodulin
|
|
gptkbp:activeSiteResidue
|
serine 195
|
|
gptkbp:alternativeName
|
gptkb:coagulation_factor_IIa
gptkb:serine_protease_1
|
|
gptkbp:associatedWith
|
hemophilia
thrombosis
|
|
gptkbp:CASNumber
|
9002-04-4
|
|
gptkbp:catalyzes
|
conversion of fibrinogen to fibrin
|
|
gptkbp:cleavage
|
gptkb:fibrinopeptide_A
gptkb:fibrinopeptide_B
|
|
gptkbp:cofactor
|
phospholipids
calcium ions
|
|
gptkbp:discoveredBy
|
gptkb:Armand_J._Quick
|
|
gptkbp:discoveredIn
|
1935
|
|
gptkbp:EC_number
|
3.4.21.5
|
|
gptkbp:expressedIn
|
liver
|
|
gptkbp:foundIn
|
gptkb:plasma
|
|
gptkbp:function
|
gptkb:serine_protease
blood coagulation
|
|
gptkbp:gene
|
gptkb:F2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
thrombin
|
|
gptkbp:inhibitedBy
|
gptkb:antithrombin
gptkb:heparin
hirudin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p11-q12
|
|
gptkbp:medicalUse
|
topical hemostatic agent
|
|
gptkbp:molecularWeight
|
approximately 37 kDa
|
|
gptkbp:PDB
|
1PPB
|
|
gptkbp:producedBy
|
prothrombinase complex
|
|
gptkbp:produces
|
prothrombin
|
|
gptkbp:relatedTo
|
secondary hemostasis
|
|
gptkbp:role
|
wound healing
angiogenesis
cell signaling
inflammation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
two polypeptide chains (A and B)
|
|
gptkbp:substrate
|
gptkb:fibrinogen
protease-activated receptors
|
|
gptkbp:UniProtID
|
P00734
|
|
gptkbp:used_in
|
fibrin sealants
laboratory coagulation tests
|
|
gptkbp:bfsParent
|
gptkb:Hirudin
|
|
gptkbp:bfsLayer
|
5
|