Statements (30)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:protein
|
gptkbp:alsoKnownAs |
gptkb:A1AT
alpha-1 proteinase inhibitor |
gptkbp:category |
acute-phase protein
serpin family |
gptkbp:deficiencyAssociatedWith |
gptkb:liver_disease
emphysema |
gptkbp:deficiencyCauses |
gptkb:alpha-1_antitrypsin_deficiency
|
gptkbp:discoveredBy |
Laurell and Eriksson
|
gptkbp:discoveredIn |
1963
|
gptkbp:encodedBy |
gptkb:SERPINA1_gene
|
gptkbp:foundIn |
blood plasma
|
gptkbp:function |
gptkb:serine_protease
|
https://www.w3.org/2000/01/rdf-schema#label |
alpha-1 antitrypsin
|
gptkbp:inhibitedBy |
neutrophil elastase
|
gptkbp:locatedOnChromosome |
14q32.13
|
gptkbp:medicalUse |
augmentation therapy
diagnosis of deficiency |
gptkbp:molecularWeight |
52 kDa
|
gptkbp:OMIM |
107400
|
gptkbp:PDB |
1QLP
|
gptkbp:producedBy |
liver
macrophages monocytes |
gptkbp:structure |
gptkb:protein
|
gptkbp:UniProtID |
P01009
|
gptkbp:bfsParent |
gptkb:elastase
gptkb:alpha-1_antitrypsin_deficiency gptkb:serpins |
gptkbp:bfsLayer |
7
|