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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
developmental disorders
|
|
gptkbp:example
|
gptkb:EGFR
gptkb:FGFR
gptkb:Insulin_receptor
gptkb:PDGFR
gptkb:VEGFR
|
|
gptkbp:fullName
|
gptkb:Receptor_Tyrosine_Kinases
|
|
gptkbp:function
|
cell signaling
regulation of cell differentiation
regulation of cell survival
regulation of cell growth
regulation of cell metabolism
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RTKs
|
|
gptkbp:inhibitedBy
|
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mechanismOfAction
|
autophosphorylation
activation of intracellular signaling pathways
ligand binding induces dimerization
|
|
gptkbp:numberOfGenes
|
58
|
|
gptkbp:proteinFamily
|
gptkb:protein_kinase_superfamily
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinases
|
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gptkbp:bfsLayer
|
5
|