proto-oncogene tyrosine-protein kinase Src

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:c-Src cellular Src pp60c-src proto-oncogene c-Src
gptkbp:associatedWith	gptkb:leukemia gptkb:cancer gptkb:glioblastoma pancreatic cancer colon cancer osteosarcoma
gptkbp:biologicalProcess	ATP binding protein tyrosine kinase activity
gptkbp:cellularComponent	gptkb:cytoplasm gptkb:plasma_membrane focal adhesion perinuclear region of cytoplasm
gptkbp:discoveredBy	gptkb:Harold_E._Varmus gptkb:J._Michael_Bishop
gptkbp:EC_number	2.7.10.2
gptkbp:encodedBy	SRC gene
gptkbp:family	gptkb:Src_family_kinases
gptkbp:firstDescribed	1978
gptkbp:function	signal transduction regulation of cell differentiation regulation of cell survival regulation of cell growth regulation of cell migration non-receptor tyrosine kinase
gptkbp:gene	gptkb:SRC
gptkbp:inhibitedBy	gptkb:bosutinib gptkb:dasatinib gptkb:ponatinib gptkb:saracatinib
gptkbp:locatedOnChromosome	20q11.23
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Src
gptkbp:PDB	gptkb:1FMK gptkb:1Y57 gptkb:2SRC
gptkbp:phosphorylates	Tyr416 Tyr527
gptkbp:related_viral_protein	gptkb:v-Src
gptkbp:related_virus	gptkb:Rous_sarcoma_virus
gptkbp:UniProtID	P12931
gptkbp:bfsParent	gptkb:Src
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	proto-oncogene tyrosine-protein kinase Src