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proto-oncogene tyrosine-protein kinase Src
URI:
https://gptkb.org/entity/proto-oncogene_tyrosine-protein_kinase_Src
GPTKB entity
Statements (49)
Predicate
Object
gptkbp:instanceOf
gptkb:protein
gptkb:enzyme
gptkbp:alternativeName
gptkb:c-Src
cellular Src
pp60c-src
proto-oncogene c-Src
gptkbp:associatedWith
gptkb:cancer
gptkb:glioblastoma
leukemia
pancreatic cancer
colon cancer
osteosarcoma
gptkbp:biologicalProcess
ATP binding
protein tyrosine kinase activity
gptkbp:cellularComponent
gptkb:cytoplasm
gptkb:plasma_membrane
focal adhesion
perinuclear region of cytoplasm
gptkbp:discoveredBy
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
gptkbp:EC_number
2.7.10.2
gptkbp:encodedBy
SRC gene
gptkbp:family
gptkb:Src_family_kinases
gptkbp:firstDescribed
1978
gptkbp:function
signal transduction
regulation of cell differentiation
regulation of cell survival
regulation of cell growth
regulation of cell migration
non-receptor tyrosine kinase
gptkbp:gene
gptkb:SRC
https://www.w3.org/2000/01/rdf-schema#label
proto-oncogene tyrosine-protein kinase Src
gptkbp:inhibitedBy
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:saracatinib
gptkbp:locatedOnChromosome
20q11.23
gptkbp:organism
gptkb:Homo_sapiens
gptkbp:orthologInMouse
gptkb:Src
gptkbp:PDB
gptkb:1FMK
gptkb:1Y57
gptkb:2SRC
gptkbp:phosphorylates
Tyr416
Tyr527
gptkbp:related_viral_protein
gptkb:v-Src
gptkbp:related_virus
gptkb:Rous_sarcoma_virus
gptkbp:UniProtID
P12931
gptkbp:bfsParent
gptkb:Src
gptkbp:bfsLayer
7