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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
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Proto-oncogene tyrosine-protein kinase Src
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gptkbp:biologicalProcess
|
ATP binding
protein tyrosine kinase activity
|
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gptkbp:cellularComponent
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gptkb:cytoplasm
gptkb:plasma_membrane
|
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gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
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gptkbp:domain
|
SH2 domain
SH3 domain
tyrosine kinase domain
|
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gptkbp:encodedBy
|
SRC gene
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gptkbp:enzymeClassification
|
EC 2.7.10.2
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|
gptkbp:firstDescribed
|
1978
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gptkbp:function
|
signal transduction
regulation of cell differentiation
regulation of cell growth
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|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Src
|
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gptkbp:inhibitedBy
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:saracatinib
|
|
gptkbp:locatedOnChromosome
|
20q11.23
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
prostate cancer
osteosarcoma
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
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gptkbp:PDB
|
gptkb:1FMK
gptkb:1Y57
gptkb:2SRC
|
|
gptkbp:phosphorylates
|
gptkb:EGFR
gptkb:FAK
gptkb:STAT3
p130Cas
|
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gptkbp:postTranslationalModification
|
phosphorylation
myristoylation
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell migration
cell adhesion
|
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gptkbp:relatedTo
|
gptkb:cancer
gptkb:v-Src
tumor suppressor
oncogenesis
|
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gptkbp:UniProtID
|
P12931
|
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gptkbp:bfsParent
|
gptkb:Src_family_kinases
gptkb:HNRNPK
|
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gptkbp:bfsLayer
|
7
|