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gptkbp:instanceOf
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gptkb:enzyme
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gptkbp:activatedBy
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gptkb:diacylglycerol_(DAG)
phorbol esters
calcium ions (for some isoforms)
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gptkbp:associatedWith
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gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
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gptkbp:catalytic_domain
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kinase activity
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gptkbp:cofactor
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gptkb:ATP
phospholipids
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gptkbp:discoveredBy
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gptkb:Yasutomi_Nishizuka
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gptkbp:discoveredIn
|
1977
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gptkbp:enzymeCommissionNumber
|
EC 2.7.11.13
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gptkbp:expressedIn
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brain
heart
liver
many tissues
immune cells
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gptkbp:family
|
serine/threonine protein kinases
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gptkbp:function
|
phosphorylation of serine and threonine residues
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gptkbp:gene
|
PRKCA (for PKC alpha)
PRKCB (for PKC beta)
PRKCD (for PKC delta)
PRKCE (for PKC epsilon)
PRKCG (for PKC gamma)
PRKCH (for PKC eta)
PRKCI (for PKC iota/lambda)
PRKCQ (for PKC theta)
PRKCZ (for PKC zeta)
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gptkbp:hasIsoform
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gptkb:PKC_alpha
gptkb:PKC_beta
gptkb:PKC_delta
gptkb:PKC_epsilon
gptkb:PKC_eta
gptkb:PKC_gamma
gptkb:PKC_theta
gptkb:PKC_zeta
PKC iota/lambda
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein kinase C (PKC)
|
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gptkbp:inhibitedBy
|
gptkb:chelerythrine
gptkb:staurosporine
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gptkbp:involves
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gptkb:MAPK_signaling_pathway
gptkb:Wnt_signaling_pathway
insulin signaling pathway
calcium signaling pathway
NF-kB signaling pathway
|
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gptkbp:molecularWeight
|
70-90 kDa (varies by isoform)
|
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gptkbp:orthologIn
|
gptkb:PRKCA
|
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gptkbp:orthologInMouse
|
Prkca
|
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gptkbp:phosphorylates
|
serine residues
threonine residues
|
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gptkbp:regulatory_domain
|
C1 domain (binds DAG and phorbol esters)
C2 domain (binds calcium in some isoforms)
|
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gptkbp:role
|
apoptosis
cell proliferation
differentiation
signal transduction
immune response
|
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gptkbp:structure
|
regulatory domain and catalytic domain
|
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gptkbp:subcellularLocation
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gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:substrate
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gptkb:histone_H1
gptkb:GAP-43
gptkb:myristoylated_alanine-rich_C-kinase_substrate
MARCKS protein
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gptkbp:bfsParent
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gptkb:IP3/DAG_pathway
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gptkbp:bfsLayer
|
6
|