staurosporine

URI: https://gptkb.org/entity/staurosporine

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:antibiotic alkaloid protease inhibitor
gptkbp:affects	apoptosis signal transduction cell cycle arrest
gptkbp:CASNumber	62996-74-1
gptkbp:chemicalFormula	C28H26N4O3
gptkbp:color	white
gptkbp:discoveredBy	Kyowa Hakko Kogyo Co.
gptkbp:discoveredIn	1977
https://www.w3.org/2000/01/rdf-schema#label	staurosporine
gptkbp:isCytotoxic	true
gptkbp:IUPACName	(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10,11-dihydroxy-9-methoxy-13-methyl-1H,9H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-one
gptkbp:mechanismOfAction	inhibits protein kinases
gptkbp:meltingPoint	230-232°C
gptkbp:molecularWeight	466.54 g/mol
gptkbp:notableDerivative	gptkb:midostaurin gptkb:lestaurtinib gptkb:enzastaurin UCN-01
gptkbp:origin	Streptomyces staurosporeus
gptkbp:producedBy	gptkb:Streptomyces_species
gptkbp:PubChem_CID	gptkb:CHEMBL413 44259 CHEBI:47224
gptkbp:solubility	gptkb:DMSO gptkb:methanol ethanol
gptkbp:structureType	indolocarbazole
gptkbp:UNII	8A1P0V6F2L
gptkbp:usedAs	research tool
gptkbp:usedIn	biochemical research
gptkbp:bfsParent	gptkb:PKC
gptkbp:bfsLayer	6