|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Protein_kinase_C_theta_type
PRKCT
|
|
gptkbp:associatedWith
|
asthma
multiple sclerosis
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
Yasutomi Nishizuka group
|
|
gptkbp:encodedBy
|
gptkb:PRKCQ_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
T lymphocytes
|
|
gptkbp:function
|
signal transduction
T cell activation
serine/threonine kinase activity
NF-κB activation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKC theta
|
|
gptkbp:inhibitedBy
|
gptkb:enzastaurin
sotrastaurin
|
|
gptkbp:interactsWith
|
gptkb:Vav1
gptkb:CD28
gptkb:Lck
gptkb:MALT1
Bcl10
CARMA1
|
|
gptkbp:involvedIn
|
inflammation
immune response
autoimmunity
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:immunological_synapse
|
|
gptkbp:locatedOnChromosome
|
human chromosome 10q21
|
|
gptkbp:memberOf
|
gptkb:protein_kinase_C_family
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
2JED
|
|
gptkbp:phosphorylates
|
CARD11
NF-κB pathway components
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
cytokine production
Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Biological_Chemistry
gptkb:Nature_Reviews_Immunology
|
|
gptkbp:structure
|
contains kinase domain
contains C1 and C2 domains
|
|
gptkbp:UniProtID
|
gptkb:Q04759
|
|
gptkbp:bfsParent
|
gptkb:PKC
|
|
gptkbp:bfsLayer
|
6
|