|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:actsOn
|
gptkb:cyclic_GMP
cyclic AMP
|
|
gptkbp:catalyzes
|
hydrolysis of phosphodiester bonds
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:EC_number
|
3.1.4.-
|
|
gptkbp:encodedBy
|
PDE genes
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Phosphodiesterase
|
|
gptkbp:inhibitedBy
|
gptkb:theophylline
gptkb:sildenafil
gptkb:milrinone
gptkb:rolipram
gptkb:tadalafil
caffeine
|
|
gptkbp:medicalUse
|
target for drugs treating depression
target for drugs treating erectile dysfunction
target for drugs treating heart failure
target for drugs treating pulmonary hypertension
|
|
gptkbp:proteinFamily
|
gptkb:PDE_family
|
|
gptkbp:regulates
|
cellular signaling
levels of cAMP
levels of cGMP
|
|
gptkbp:relatedTo
|
signal transduction
second messenger systems
|
|
gptkbp:structure
|
contains catalytic domain
may contain regulatory domains
|
|
gptkbp:subclassOf
|
gptkb:phosphodiesterase_type_1
gptkb:phosphodiesterase_type_10
gptkb:phosphodiesterase_type_11
gptkb:phosphodiesterase_type_2
gptkb:phosphodiesterase_type_3
gptkb:phosphodiesterase_type_4
gptkb:phosphodiesterase_type_5
gptkb:phosphodiesterase_type_6
gptkb:phosphodiesterase_type_7
gptkb:phosphodiesterase_type_8
gptkb:phosphodiesterase_type_9
|
|
gptkbp:usedIn
|
gptkb:pharmacy
biochemistry
molecular biology
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|