Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:hypoxia
|
| gptkbp:composedOf |
gptkb:HIF-1α
gptkb:HIF-1β |
| gptkbp:degradedBy |
gptkb:proteasome
gptkb:prolyl_hydroxylase gptkb:von_Hippel-Lindau_protein |
| gptkbp:discoveredBy |
gptkb:Gregg_L._Semenza
|
| gptkbp:foundIn |
mammals
other animals |
| gptkbp:function |
regulates cellular response to low oxygen
|
| gptkbp:gene |
ARNT (for HIF-1β)
HIF1A (for HIF-1α) |
| https://www.w3.org/2000/01/rdf-schema#label |
HIF
|
| gptkbp:NobelPrizeYear |
gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
|
| gptkbp:regulates |
cell proliferation
angiogenesis glycolysis VEGF expression cell survival under hypoxia erythropoietin gene expression glucose transporter expression |
| gptkbp:relatedTo |
gptkb:cancer
gptkb:anemia ischemia |
| gptkbp:standsFor |
gptkb:Hypoxia-inducible_factor
|
| gptkbp:bfsParent |
gptkb:Huddinge_IF
gptkb:Hill_Air_Force_Base gptkb:Helsingborgs_IF |
| gptkbp:bfsLayer |
6
|