Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
phytochemical
|
| gptkbp:bioavailability |
low
|
| gptkbp:CASNumber |
11079-53-1
|
| gptkbp:chemicalClass |
phloroglucinol derivative
|
| gptkbp:color |
yellow-orange
|
| gptkbp:component |
St. John's Wort extract
|
| gptkbp:discoveredIn |
1975
|
| gptkbp:drugClass |
anti-inflammatory
antibacterial antidepressant |
| gptkbp:foundIn |
gptkb:Hypericum_perforatum
|
| gptkbp:hasMolecularFormula |
C35H52O4
|
| gptkbp:hasSMILES |
CC(C)C(=O)O[C@H]1CC[C@@]2(C)[C@H]3CC=C(C)[C@@H]4CC(C)(C)C(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
|
| gptkbp:hasTherapeuticUse |
treatment of mild to moderate depression
|
| https://www.w3.org/2000/01/rdf-schema#label |
hyperforin
|
| gptkbp:isExtractedFrom |
flowers of Hypericum perforatum
|
| gptkbp:isNotApprovedBy |
gptkb:FDA
|
| gptkbp:IUPACName |
2-(2-methylpropanoyl)-3,8,13,13-tetramethyl-18-(2-methylpropanoyloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17,18,19,20-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl 2-methylpropanoate
|
| gptkbp:mechanismOfAction |
activates TRPC6 channels
inhibits reuptake of neurotransmitters |
| gptkbp:metabolism |
rapidly metabolized in the liver
|
| gptkbp:molecularWeight |
536.78 g/mol
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL1234562
5280863 |
| gptkbp:sensitivity |
oxygen
heat light |
| gptkbp:sideEffect |
photosensitivity
drug interactions |
| gptkbp:solubility |
poorly soluble in water
soluble in organic solvents |
| gptkbp:toxicity |
low in humans
|
| gptkbp:bfsParent |
gptkb:St._John's_Wort
|
| gptkbp:bfsLayer |
6
|