phospholipase C gamma (PLCγ)

URI: https://gptkb.org/entity/phospholipase_C_gamma_(PLCγ)
GPTKB entity
Statements (38)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:receptor_tyrosine_kinases
phosphorylation
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
gptkbp:biologicalProcess phospholipase activity
phosphoric diester hydrolase activity
gptkbp:catalyzes hydrolysis of PIP2 to IP3 and DAG
gptkbp:discoveredBy gptkb:Kazuo_Suzuki
gptkbp:discoveredIn 1989
gptkbp:domain SH2 domain
SH3 domain
gptkbp:encodedBy PLCG1 gene
PLCG2 gene
gptkbp:enzymeCommissionNumber EC 3.1.4.11
gptkbp:hasIsoform gptkb:PLCγ1
gptkb:PLCγ2
https://www.w3.org/2000/01/rdf-schema#label phospholipase C gamma (PLCγ)
gptkbp:interactsWith gptkb:EGFR
gptkb:FGFR
gptkb:PDGFR
gptkb:Syk
gptkb:ZAP-70
gptkb:LAT
gptkbp:involvedIn signal transduction
calcium signaling
gptkbp:locale gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight ~150 kDa
gptkbp:participatedIn growth factor signaling
immune cell signaling
gptkbp:regulates cell differentiation
cell proliferation
cell migration
gptkbp:UniProtID P16885
P19174
gptkbp:bfsParent gptkb:PLCγ_pathway
gptkbp:bfsLayer 7