|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
environmental stress
pro-inflammatory cytokines
|
|
gptkbp:alternativeName
|
gptkb:MAPK14
gptkb:Mitogen-activated_protein_kinase_14
gptkb:CSBP
gptkb:SAPK2a
RK
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:MAPK14_gene
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:function
|
signal transduction
inflammatory response
cellular response to stress
|
|
gptkbp:hasIsoform
|
gptkb:p38α
gptkb:p38β
gptkb:p38γ
gptkb:p38δ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p38 MAP kinase
|
|
gptkbp:inhibitedBy
|
gptkb:SB203580
gptkb:BIRB_796
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
~38 kDa
|
|
gptkbp:orthologIn
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
|
|
gptkbp:phosphorylates
|
gptkb:tyrosine
transcription factors
other kinases
threonine
|
|
gptkbp:regulates
|
cell survival
gene expression
protein synthesis
|
|
gptkbp:relatedTo
|
gptkb:ERK_pathway
gptkb:JNK_pathway
|
|
gptkbp:role
|
gptkb:cancer
apoptosis
cell differentiation
cell cycle regulation
neurodegenerative diseases
cardiovascular diseases
inflammation
immune response
|
|
gptkbp:structure
|
serine/threonine kinase domain
|
|
gptkbp:subunit
|
gptkb:MAPK_pathway
|
|
gptkbp:bfsParent
|
gptkb:MAPKAPK2
gptkb:MAPKAPK3
gptkb:MAPKAPK5
gptkb:PRKMK2
gptkb:SB203580
|
|
gptkbp:bfsLayer
|
7
|