Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeTo |
gptkb:p190_BCR-ABL
gptkb:p230_BCR-ABL |
| gptkbp:associatedWith |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:cause |
uncontrolled cell proliferation
constitutive activation of ABL kinase |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:encodedBy |
gptkb:BCR-ABL_fusion_gene
|
| gptkbp:hasBiologicalActivity |
gptkb:receptor_tyrosine_kinase
|
| gptkbp:hasComponent |
gptkb:ABL1_gene
BCR gene |
| https://www.w3.org/2000/01/rdf-schema#label |
p210 BCR-ABL
|
| gptkbp:locatedOn |
chromosome 22 (Philadelphia chromosome)
|
| gptkbp:molecularWeight |
210 kDa
|
| gptkbp:product |
gptkb:Philadelphia_chromosome
|
| gptkbp:target |
gptkb:bosutinib
gptkb:dasatinib gptkb:ponatinib gptkb:imatinib gptkb:nilotinib |
| gptkbp:bfsParent |
gptkb:BCR-ABL
|
| gptkbp:bfsLayer |
6
|