neurotrophic tyrosine kinase receptor type 1

URI: https://gptkb.org/entity/neurotrophic_tyrosine_kinase_receptor_type_1
GPTKB entity
Statements (28)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alsoKnownAs gptkb:TrkA
gptkbp:associatedWith gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkbp:biologicalProcess gptkb:neurotrophin_signaling_pathway
transmembrane receptor protein tyrosine kinase activity
gptkbp:discoveredBy gptkb:L._F._Reichardt
gptkbp:discoveredIn 1986
gptkbp:encodedBy gptkb:NTRK1_gene
gptkbp:Entrez_Gene_ID ENSG00000198400
gptkbp:expressedIn gptkb:nervous_system
gptkbp:function tyrosine kinase activity
high affinity nerve growth factor receptor
gptkbp:gene gptkb:NTRK1
gptkbp:HGNC_ID 8031
https://www.w3.org/2000/01/rdf-schema#label neurotrophic tyrosine kinase receptor type 1
gptkbp:ligand gptkb:nerve_growth_factor_(NGF)
gptkbp:locatedOnChromosome chromosome 1
gptkbp:location gptkb:cell_membrane
gptkbp:mutationAssociatedWith neurological disorders
gptkbp:OMIM 191315
gptkbp:PDB gptkb:1WWW
gptkbp:targetOfDrug gptkb:entrectinib
gptkb:larotrectinib
gptkbp:UniProtID gptkb:P04629
gptkbp:bfsParent gptkb:tropomyosin_receptor_kinase_A
gptkbp:bfsLayer 7