brain-derived neurotrophic factor (BDNF)

URI: https://gptkb.org/entity/brain-derived_neurotrophic_factor_(BDNF)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
neurotrophin
gptkbp:affects gptkb:synaptic_plasticity
memory
learning
synaptic transmission
neuronal differentiation
neuronal survival
energy metabolism
mood regulation
gptkbp:alternativeSplicing yes
gptkbp:cleavage gptkb:mature_BDNF
gptkbp:discoveredBy gptkb:Yves-Alain_Barde
gptkbp:discoveredIn 1982
gptkbp:encodedBy gptkb:BDNF_gene
gptkbp:expressedIn brain
peripheral tissues
gptkbp:foundIn gptkb:human
mammals
gptkbp:function supports survival of existing neurons
involved in synaptic plasticity
encourages growth and differentiation of new neurons and synapses
involved in long-term memory
gptkbp:HGNC_ID 1033
https://www.w3.org/2000/01/rdf-schema#label brain-derived neurotrophic factor (BDNF)
gptkbp:influencedBy gptkb:food
stress
physical activity
gptkbp:locatedOnChromosome gptkb:chromosome_11_(human)
gptkbp:molecularWeight ~27 kDa (mature form)
gptkbp:mutationAssociatedWith gptkb:Val66Met
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:predecessor gptkb:proBDNF
gptkbp:recipient gptkb:p75NTR
gptkb:TrkB
gptkbp:relatedTo gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:depression
epilepsy
schizophrenia
obesity
exercise
gptkbp:UniProtID gptkb:P23560
gptkbp:Val66Met affects activity-dependent secretion
associated with psychiatric disorders
gptkbp:bfsParent gptkb:CD271
gptkb:NTF3
gptkb:Ngfr
gptkbp:bfsLayer 8