tissue inhibitors of metalloproteinases (TIMPs)
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
TIMPs
|
| gptkbp:alternativeName |
metalloproteinase inhibitors
|
| gptkbp:binds |
gptkb:matrix_metalloproteinases
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:expressedIn |
many tissues
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
inhibit matrix metalloproteinases (MMPs)
|
| https://www.w3.org/2000/01/rdf-schema#label |
tissue inhibitors of metalloproteinases (TIMPs)
|
| gptkbp:involves |
wound healing
angiogenesis tumor progression tissue remodeling |
| gptkbp:locatedOnChromosome |
varies by TIMP type
|
| gptkbp:member |
gptkb:TIMP1
gptkb:TIMP2 gptkb:TIMP3 gptkb:TIMP4 |
| gptkbp:molecularWeight |
~21-29 kDa
|
| gptkbp:regulates |
extracellular matrix remodeling
transcriptional and post-transcriptional |
| gptkbp:significance |
gptkb:cancer
gptkb:cardiovascular_disease fibrosis |
| gptkbp:structure |
N-terminal and C-terminal domains
|
| gptkbp:bfsParent |
gptkb:MMP1
|
| gptkbp:bfsLayer |
7
|