matrix metallopeptidase 1

URI: https://gptkb.org/entity/matrix_metallopeptidase_1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:collagenase-1 fibroblast collagenase
gptkbp:associatedWith	gptkb:cancer osteoarthritis rheumatoid arthritis fibrosis
gptkbp:cellularComponent	extracellular space
gptkbp:cleavage_site	collagen triple helix
gptkbp:discoveredBy	1976
gptkbp:enzymeCommissionNumber	EC 3.4.24.7
gptkbp:expressedIn	macrophages fibroblasts epithelial cells
gptkbp:function	degrades interstitial collagens
gptkbp:gene	gptkb:MMP1
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	HGNC:7155
https://www.w3.org/2000/01/rdf-schema#label	matrix metallopeptidase 1
gptkbp:inhibitedBy	gptkb:tissue_inhibitors_of_metalloproteinases_(TIMPs)
gptkbp:involves	wound healing arthritis extracellular matrix remodeling tissue remodeling tumor invasion
gptkbp:locatedIn	chromosome 11q22.2
gptkbp:locatedOnChromosome	chr11:102,660,799-102,666,935
gptkbp:member	gptkb:matrix_metalloproteinase_family
gptkbp:molecularWeight	43 kDa (active enzyme) 54 kDa (proenzyme)
gptkbp:OMIM	120353
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	Mmp1a Mmp1b
gptkbp:PDB	1CGL
gptkbp:postTranslationalModification	glycosylation proteolytic activation
gptkbp:RefSeq	NM_002421
gptkbp:regulates	cytokines growth factors hormones
gptkbp:structure	contains zinc-binding motif
gptkbp:substrate	gptkb:collagen_type_I gptkb:collagen_type_II gptkb:collagen_type_III
gptkbp:transcription_factor_binding_site	gptkb:NF-κB gptkb:AP-1
gptkbp:UniProtID	P03956
gptkbp:bfsParent	gptkb:MMP1
gptkbp:bfsLayer	7