Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:alsoKnownAs |
gptkb:MMP-1
matrix metalloproteinase-1 |
| gptkbp:cofactor |
zinc
calcium |
| gptkbp:EC_number |
3.4.24.7
|
| gptkbp:encodedBy |
MMP1 gene
|
| gptkbp:family |
gptkb:matrix_metalloproteinase_family
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
degrades interstitial collagens
|
| https://www.w3.org/2000/01/rdf-schema#label |
collagenase-1
|
| gptkbp:inhibitedBy |
gptkb:tissue_inhibitors_of_metalloproteinases_(TIMPs)
|
| gptkbp:locatedOnChromosome |
11q22.3 (human)
|
| gptkbp:molecularWeight |
54 kDa (proenzyme)
|
| gptkbp:role |
wound healing
arthritis tissue remodeling tumor invasion |
| gptkbp:structure |
contains catalytic domain
contains hemopexin-like domain |
| gptkbp:substrate |
gptkb:collagen_type_I
gptkb:collagen_type_II gptkb:collagen_type_III |
| gptkbp:bfsParent |
gptkb:MMP1
|
| gptkbp:bfsLayer |
7
|