|
gptkbp:instanceOf
|
gptkb:protein
gptkb:collagen
|
|
gptkbp:associatedWith
|
gptkb:Stickler_syndrome
osteoarthritis
spondyloepiphyseal dysplasia congenita
|
|
gptkbp:biosynthesized_from
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:crosslinking
|
lysyl oxidase-mediated
|
|
gptkbp:degradedBy
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:discoveredBy
|
Björn Engfeldt
|
|
gptkbp:encodedBy
|
gptkb:COL2A1_gene
|
|
gptkbp:foundIn
|
gptkb:nucleus_pulposus
gptkb:collagen
vitreous humor
|
|
gptkbp:function
|
provides tensile strength to cartilage
forms fibrils in cartilage matrix
|
|
gptkbp:location
|
gptkb:extracellular_matrix
|
|
gptkbp:molecularWeight
|
~300 kDa
|
|
gptkbp:OMIM
|
120140
|
|
gptkbp:postTranslationalModification
|
hydroxylation of proline and lysine
|
|
gptkbp:structure
|
triple helix
|
|
gptkbp:subunit
|
three alpha-1(II) chains
|
|
gptkbp:UniProtID
|
gptkb:P02458
|
|
gptkbp:usedAs
|
biomarker for cartilage degradation
|
|
gptkbp:usedIn
|
cartilage repair therapies
|
|
gptkbp:bfsParent
|
gptkb:MMP1
gptkb:MMP13
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
collagen type II
|