Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
collagen |
| gptkbp:associatedWith |
gptkb:Stickler_syndrome
osteoarthritis spondyloepiphyseal dysplasia congenita |
| gptkbp:biosynthesized_from |
gptkb:endoplasmic_reticulum
|
| gptkbp:crosslinking |
lysyl oxidase-mediated
|
| gptkbp:degradedBy |
gptkb:matrix_metalloproteinases
|
| gptkbp:discoveredBy |
Björn Engfeldt
|
| gptkbp:encodedBy |
gptkb:COL2A1_gene
|
| gptkbp:foundIn |
gptkb:nucleus_pulposus
collagen vitreous humor |
| gptkbp:function |
provides tensile strength to cartilage
forms fibrils in cartilage matrix |
| https://www.w3.org/2000/01/rdf-schema#label |
collagen type II
|
| gptkbp:location |
extracellular matrix
|
| gptkbp:molecularWeight |
~300 kDa
|
| gptkbp:OMIM |
120140
|
| gptkbp:postTranslationalModification |
hydroxylation of proline and lysine
|
| gptkbp:structure |
triple helix
|
| gptkbp:subunit |
three alpha-1(II) chains
|
| gptkbp:UniProtID |
gptkb:P02458
|
| gptkbp:usedAs |
biomarker for cartilage degradation
|
| gptkbp:usedIn |
cartilage repair therapies
|
| gptkbp:bfsParent |
gptkb:MMP1
gptkb:MMP13 |
| gptkbp:bfsLayer |
7
|