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gptkbp:instanceOf
|
biochemical phenomenon
|
|
gptkbp:affects
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acidification of tumor microenvironment
biosynthesis of macromolecules
cellular energy production
redox balance
|
|
gptkbp:characterizedBy
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increased glucose uptake
lactate production in presence of oxygen
|
|
gptkbp:contrastsWith
|
normal cellular respiration
|
|
gptkbp:describes
|
aerobic glycolysis
|
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gptkbp:firstDescribed
|
1920s
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Warburg effect
|
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gptkbp:implies
|
immunotherapy
drug resistance
cancer prognosis
metabolic reprogramming
therapeutic targeting
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:glucose_transporters
gptkb:hexokinase
gptkb:hypoxia-inducible_factor_1_(HIF-1)
gptkb:lactate_dehydrogenase
gptkb:pyruvate
gptkb:pyruvate_kinase
cancer diagnosis
oncogenes
mitochondria
glycolysis
tumor growth
tumor suppressor genes
|
|
gptkbp:mechanismInvolves
|
altered mitochondrial function
|
|
gptkbp:namedAfter
|
gptkb:Otto_Warburg
|
|
gptkbp:observedBy
|
cancer cells
|
|
gptkbp:relatedTo
|
gptkb:Crabtree_effect
gptkb:Pasteur_effect
oncology
metabolism
|
|
gptkbp:studiedBy
|
biochemists
cancer researchers
|
|
gptkbp:usedIn
|
gptkb:positron_emission_tomography_(PET)_imaging
|
|
gptkbp:bfsParent
|
gptkb:Otto_Warburg
|
|
gptkbp:bfsLayer
|
4
|