glucose transporter 1 (GLUT1)

URI: https://gptkb.org/entity/glucose_transporter_1_(GLUT1)

GPTKB entity

Statements (50)

Predicate	Object
gptkbp:instanceOf	gptkb:protein ABC transporter
gptkbp:alternativeName	gptkb:SLC2A1 gptkb:solute_carrier_family_2,_facilitated_glucose_transporter_member_1
gptkbp:associatedWith	gptkb:De_Vivo_disease gptkb:GLUT1_deficiency_syndrome
gptkbp:clinicalTrialPhase	gptkb:GLUT1_deficiency_genetic_test
gptkbp:discoveredBy	gptkb:Mike_Mueckler
gptkbp:discoveredIn	1985
gptkbp:encodedBy	gptkb:SLC2A1_gene
gptkbp:Entrez_Gene_ID	6513
gptkbp:expressedIn	gptkb:placenta gptkb:blood-brain_barrier endothelial cells erythrocytes fetal tissues
gptkbp:family	gptkb:major_facilitator_superfamily
gptkbp:function	facilitated diffusion of glucose
gptkbp:HGNC_ID	11005
https://www.w3.org/2000/01/rdf-schema#label	glucose transporter 1 (GLUT1)
gptkbp:inhibitedBy	gptkb:cytochalasin_B
gptkbp:length	492
gptkbp:locatedOnChromosome	gptkb:1p34.2
gptkbp:location	gptkb:plasma_membrane
gptkbp:molecularWeight	54 kDa
gptkbp:mutationAssociatedWith	gptkb:GLUT1_deficiency_syndrome
gptkbp:OMIM	138140
gptkbp:orthologIn	present in mammals
gptkbp:PDB	4PYP
gptkbp:regulates	upregulated by hypoxia regulated by insulin regulated by glucose levels
gptkbp:relatedTo	gptkb:GLUT4 gptkb:GLUT2 gptkb:GLUT3
gptkbp:requires	glucose uptake in brain
gptkbp:significance	epilepsy movement disorders developmental delay
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:structure	12 transmembrane helices
gptkbp:substrate	gptkb:dehydroascorbic_acid glucose
gptkbp:transmembraneDomains	12
gptkbp:transportMechanism	facilitated diffusion
gptkbp:UniProtID	P11166
gptkbp:usedIn	diagnosis of GLUT1 deficiency
gptkbp:bfsParent	gptkb:hypoxia-inducible_factor_1_(HIF-1)
gptkbp:bfsLayer	6