vascular endothelial growth factor (VEGF)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein growth factor
gptkbp:abbreviation	gptkb:VEGF
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:cancer psoriasis retinopathy of prematurity rheumatoid arthritis pre-eclampsia neovascular glaucoma
gptkbp:discoveredBy	gptkb:Napoleone_Ferrara
gptkbp:discoveredIn	1989
gptkbp:encodedBy	gptkb:VEGFA_gene
gptkbp:Entrez_Gene_ID	7422
gptkbp:family	gptkb:VEGF_family
gptkbp:function	increases vascular permeability promotes endothelial cell growth stimulates angiogenesis
gptkbp:hasIsoform	gptkb:VEGF-A gptkb:VEGF-B gptkb:VEGF-E gptkb:VEGF-F gptkb:VEGF-C gptkb:VEGF-D
https://www.w3.org/2000/01/rdf-schema#label	vascular endothelial growth factor (VEGF)
gptkbp:involvedIn	wound healing age-related macular degeneration diabetic retinopathy tumor growth
gptkbp:locatedOnChromosome	gptkb:6p21.1
gptkbp:memberOf	gptkb:VEGF_family
gptkbp:MIM_number	192240
gptkbp:molecularWeight	~45 kDa (dimer)
gptkbp:orthologIn	gptkb:mouse gptkb:zebrafish right
gptkbp:producedBy	macrophages endothelial cells tumor cells
gptkbp:promotion	gptkb:hypoxia
gptkbp:recipient	gptkb:VEGFR-1 gptkb:VEGFR-2 gptkb:VEGFR-3
gptkbp:regulates	downregulated by anti-VEGF drugs upregulated by hypoxia-inducible factor 1 (HIF-1)
gptkbp:structure	homodimer
gptkbp:target	gptkb:bevacizumab gptkb:aflibercept gptkb:ranibizumab
gptkbp:UniProtID	P15692
gptkbp:bfsParent	gptkb:VEGFR gptkb:hypoxia-inducible_factor_1_(HIF-1)
gptkbp:bfsLayer	6