BRCA1 mutation

GPTKB entity

Statements (58)
Predicate Object
gptkbp:instance_of gptkb:Genetics
gptkbp:associated_with gptkb:Oncology
ovarian cancer
gptkbp:can_detect blood test
gptkbp:can_lead_to early onset of cancer
gptkbp:can_result_in genomic instability
gptkbp:cause defective DNA repair
gptkbp:discovered_by human genome
https://www.w3.org/2000/01/rdf-schema#label BRCA1 mutation
gptkbp:influence treatment decisions
gptkbp:inherits_from autosomal dominant inheritance
gptkbp:investigates preventive measures
genetic epidemiology
gene therapy possibilities
gptkbp:investment gptkb:Oncology
gptkb:pancreatic_cancer
gptkbp:is_analyzed_in population studies
its role in cancer progression
gptkbp:is_associated_with increased mortality risk
healthcare access issues
reproductive health issues
psychosocial impacts
male breast cancer
gptkbp:is_common_in gptkb:Ashkenazi_Jewish_population
gptkbp:is_considered a hereditary condition
a public health concern
a factor in treatment planning
a significant health risk
gptkbp:is_documented_in gptkb:literature
gptkbp:is_evaluated_by risk reduction strategies
gptkbp:is_examined_in clinical trials
longitudinal studies
gptkbp:is_explored_in epidemiological studies
gptkbp:is_linked_to gptkb:hereditary_breast_and_ovarian_cancer_syndrome
informed consent processes
increased surveillance
fallopian tube cancer
tumor suppressor gene dysfunction
increased screening recommendations
gptkbp:is_located_in chromosome 17
gptkbp:is_part_of gptkb:BRCA_gene_family
gptkb:guidelines
risk assessment protocols
patient education materials
genetic databases
cancer genetic counseling
gptkbp:is_recognized_as gptkb:1990
gptkbp:is_recognized_by genetic testing
gptkbp:is_related_to breast cancer susceptibility
gptkbp:is_studied_for its prevalence in different populations
gptkbp:is_studied_in cancer research
gptkbp:is_subject_to public health campaigns
gptkbp:is_tested_for genetic screening programs
in family history assessments
gptkbp:requires preventive surgery
gptkbp:treatment targeted therapy
gptkbp:bfsParent gptkb:Ovarian_Cancer
gptkbp:bfsLayer 5