Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:associated_with |
increased cancer risk
STK11 gene mutations |
| gptkbp:can_be_used_to |
gastrointestinal bleeding
hamartomatous polyps intussusception melanotic macules |
| gptkbp:can_detect |
family history
|
| gptkbp:can_lead_to |
gptkb:Oncology
gptkb:pancreatic_cancer ovarian cancer gastrointestinal cancers |
| gptkbp:cause |
intestinal polyps
|
| gptkbp:characterized_by |
mucocutaneous pigmentation
|
| gptkbp:diagnosis |
genetic testing
|
| gptkbp:first_described_by |
gptkb:1949
|
| https://www.w3.org/2000/01/rdf-schema#label |
Peutz-Jeghers syndrome
|
| gptkbp:inherits_from |
autosomal dominant inheritance
|
| gptkbp:is_associated_with |
increased surveillance recommendations
risk of other cancers |
| gptkbp:is_characterized_by |
pigmented lesions on the buccal mucosa
pigmented lesions on the fingers pigmented lesions on the lips polyps in the gastrointestinal tract |
| gptkbp:is_common_in |
certain ethnic groups
|
| gptkbp:is_considered |
a hereditary cancer syndrome
|
| gptkbp:is_described_as |
genetic counseling guidelines
|
| gptkbp:is_documented_in |
gptkb:literature
|
| gptkbp:is_linked_to |
germline mutations
lifetime cancer risk |
| gptkbp:is_managed_by |
multidisciplinary teams
|
| gptkbp:is_monitored_by |
cancer development
|
| gptkbp:is_noted_for |
its incomplete penetrance
its variable expressivity |
| gptkbp:is_part_of |
hereditary cancer syndromes
|
| gptkbp:is_recognized_by |
gptkb:healthcare_professionals
|
| gptkbp:is_studied_in |
oncology
gastroenterology clinical genetics |
| gptkbp:named_after |
Herman Jeghers
Jan Peutz |
| gptkbp:prevalence |
1 in 25,000 to 300,000 births
|
| gptkbp:requires |
surgical interventions
endoscopic procedures |
| gptkbp:symptoms |
nausea
abdominal pain diarrhea freckling |
| gptkbp:treatment |
surveillance for cancer
surgical removal of polyps |
| gptkbp:bfsParent |
gptkb:Epithelial_ovarian_cancer
|
| gptkbp:bfsLayer |
6
|