Statements (80)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:affects |
gptkb:TP53_gene
cellular metabolism treatment response |
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:can_detect |
genetic testing
tumor biopsies |
| gptkbp:can_lead_to |
cell cycle dysregulation
tumor heterogeneity metastasis altered signaling pathways |
| gptkbp:can_result_in |
apoptosis evasion
|
| gptkbp:cause |
loss of tumor suppressor function
|
| gptkbp:has_a_focus_on |
personalized medicine
cancer research biomedical research genetic counseling molecular biology studies |
| https://www.w3.org/2000/01/rdf-schema#label |
TP53 mutation
|
| gptkbp:increased |
genomic instability
|
| gptkbp:influence |
immune response
|
| gptkbp:inherits_from |
gptkb:Li-Fraumeni_syndrome
|
| gptkbp:insignia |
many tumors
|
| gptkbp:is_a_biomarker_for |
tumor progression
|
| gptkbp:is_a_common_alteration_in |
solid tumors
|
| gptkbp:is_a_subject_of |
gptkb:guidelines
molecular diagnostics public health research clinical trials for targeted therapies |
| gptkbp:is_analyzed_in |
genomic studies
|
| gptkbp:is_associated_with |
disease progression
epigenetic changes viral infections therapeutic resistance chemoresistance treatment resistance increased mutation burden tumor recurrence survival outcomes. |
| gptkbp:is_characterized_by |
specific nucleotide changes
|
| gptkbp:is_found_in |
various human cancers
|
| gptkbp:is_influenced_by |
lifestyle factors
|
| gptkbp:is_involved_in |
cellular homeostasis
cellular stress response DNA repair mechanisms cellular senescence tumor microenvironment cellular differentiation oncogenic signaling cellular apoptosis tumor evolution tumor suppression mechanisms |
| gptkbp:is_linked_to |
age-related diseases
chronic diseases metabolic syndrome radiation exposure genetic predisposition chemical exposure chronic inflammation poor prognosis environmental carcinogens |
| gptkbp:is_often_seen_in |
gptkb:Oncology
|
| gptkbp:is_studied_for |
early detection methods
therapeutic implications |
| gptkbp:is_studied_in |
clinical trials
pharmacogenomics |
| gptkbp:is_targeted_at |
small molecules
|
| gptkbp:participated_in |
environmental factors
|
| gptkbp:scientific_classification |
frameshift mutation
missense mutation nonsense mutation |
| gptkbp:targets |
gptkb:gene_therapy
gptkb:immunotherapy |
| gptkbp:was_a_factor_in |
tumorigenesis
clinical outcomes treatment planning cancer prevention strategies patient stratification |
| gptkbp:bfsParent |
gptkb:Oncology
|
| gptkbp:bfsLayer |
4
|