|
gptkbp:instanceOf
|
gptkb:drug
gptkb:anticoagulant
polysaccharide
|
|
gptkbp:antidote
|
gptkb:protamine_sulfate
|
|
gptkbp:approvedBy
|
1930s
|
|
gptkbp:ATCCode
|
gptkb:B01AB01
|
|
gptkbp:brand
|
gptkb:Calciparine
gptkb:Heparin_Sodium
gptkb:Liquaemin
|
|
gptkbp:CASNumber
|
9005-49-6
|
|
gptkbp:chemicalFormula
|
(C12H19NO20S3)n
|
|
gptkbp:color
|
white to off-white
|
|
gptkbp:contraindication
|
active bleeding
history of heparin-induced thrombocytopenia
severe thrombocytopenia
|
|
gptkbp:discoveredBy
|
gptkb:Jay_McLean
|
|
gptkbp:discoveredIn
|
1916
|
|
gptkbp:eliminationHalfLife
|
1-2 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:foundIn
|
gptkb:mast_cells
|
|
gptkbp:hasLowMolecularWeightForm
|
gptkb:enoxaparin
gptkb:dalteparin
gptkb:tinzaparin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
heparin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits factor Xa
inhibits thrombin
|
|
gptkbp:meshID
|
D006492
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
3,000–30,000 Da
|
|
gptkbp:monitors
|
platelet count
aPTT
|
|
gptkbp:pregnancyCategory
|
safe in pregnancy
|
|
gptkbp:producedBy
|
bovine lung
porcine intestinal mucosa
|
|
gptkbp:PubChem_CID
|
22833565
DB01109
|
|
gptkbp:riskFactor
|
gptkb:heparin-induced_thrombocytopenia
osteoporosis (with long-term use)
|
|
gptkbp:routeOfAdministration
|
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
bleeding
thrombocytopenia
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:UNII
|
GGO4Y809LO
|
|
gptkbp:usedFor
|
prevention of blood clots
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Hirudin
|
|
gptkbp:bfsLayer
|
5
|