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gptkbp:instanceOf
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gptkb:protein
gptkb:molecular_chaperone
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gptkbp:alternativeName
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gptkb:HSP90
gptkb:HSPC
gptkb:Hsp90
heat shock protein HSP 90
|
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gptkbp:cofactor
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gptkb:ATP
|
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gptkbp:conservedIn
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prokaryotes
eukaryotes
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gptkbp:encodedBy
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gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
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gptkbp:family
|
heat shock protein family
|
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gptkbp:foundIn
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gptkb:Bacteria
eukaryotes
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gptkbp:function
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gptkb:cellular_stress_response
signal transduction
protein folding
protein degradation
protein stabilization
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gptkbp:inhibitedBy
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gptkb:geldanamycin
gptkb:radicicol
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gptkbp:interactsWith
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gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
co-chaperones
|
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gptkbp:locale
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gptkb:endoplasmic_reticulum
gptkb:cytoplasm
mitochondria
|
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gptkbp:locatedOnChromosome
|
chromosome 12 (HSP90B1)
chromosome 14 (HSP90AA1)
chromosome 6 (HSP90AB1)
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gptkbp:molecularWeight
|
~90 kDa
|
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gptkbp:regulates
|
gptkb:histone_modification
transcriptional regulation
heat shock response
|
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gptkbp:requires
|
development
signal transduction
cell viability
|
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gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
protein homeostasis
|
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gptkbp:significance
|
target for cancer therapy
target for neurodegenerative disease therapy
|
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gptkbp:structure
|
homodimer
N-terminal ATPase domain
middle domain
C-terminal dimerization domain
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gptkbp:subfamily
|
gptkb:HSP90_family
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gptkbp:bfsParent
|
gptkb:Aryl_hydrocarbon_receptor_pathway
gptkb:geldanamycin
gptkb:WBP51_protein
|
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gptkbp:bfsLayer
|
8
|
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https://www.w3.org/2000/01/rdf-schema#label
|
heat shock protein 90
|