Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
molecular chaperone |
| gptkbp:alternativeName |
gptkb:HSP90
gptkb:HSPC gptkb:Hsp90 heat shock protein HSP 90 |
| gptkbp:cofactor |
gptkb:ATP
|
| gptkbp:conservedIn |
prokaryotes
eukaryotes |
| gptkbp:encodedBy |
gptkb:HSP90AA1
gptkb:HSP90AB1 gptkb:HSP90B1 |
| gptkbp:family |
heat shock protein family
|
| gptkbp:foundIn |
gptkb:Bacteria
eukaryotes |
| gptkbp:function |
signal transduction
protein folding protein degradation cellular stress response protein stabilization |
| https://www.w3.org/2000/01/rdf-schema#label |
heat shock protein 90
|
| gptkbp:inhibitedBy |
gptkb:geldanamycin
gptkb:radicicol |
| gptkbp:interactsWith |
gptkb:steroid_hormone_receptors
gptkb:kinases transcription factors co-chaperones |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:cytoplasm mitochondria |
| gptkbp:locatedOnChromosome |
chromosome 12 (HSP90B1)
chromosome 14 (HSP90AA1) chromosome 6 (HSP90AB1) |
| gptkbp:molecularWeight |
~90 kDa
|
| gptkbp:regulates |
histone modification
transcriptional regulation heat shock response |
| gptkbp:requires |
development
signal transduction cell viability |
| gptkbp:role |
gptkb:cancer
neurodegenerative diseases protein homeostasis |
| gptkbp:significance |
target for cancer therapy
target for neurodegenerative disease therapy |
| gptkbp:structure |
homodimer
N-terminal ATPase domain middle domain C-terminal dimerization domain |
| gptkbp:subfamily |
gptkb:HSP90_family
|
| gptkbp:bfsParent |
gptkb:Aryl_hydrocarbon_receptor_pathway
gptkb:geldanamycin gptkb:WBP51_protein |
| gptkbp:bfsLayer |
8
|