Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
steroid hormones
|
| gptkbp:binds |
gptkb:androgens
gptkb:glucocorticoids mineralocorticoids estrogens progestogens |
| gptkbp:cofactor |
coactivators
corepressors |
| gptkbp:discoveredBy |
gptkb:Elwood_V._Jensen
|
| gptkbp:example |
gptkb:androgen_receptor
estrogen receptor glucocorticoid receptor progesterone receptor mineralocorticoid receptor |
| gptkbp:foundIn |
humans
mammals vertebrates |
| gptkbp:function |
regulate gene expression
bind steroid hormones |
| gptkbp:gene |
gptkb:PGR
gptkb:ESR1 AR NR3C1 NR3C2 |
| https://www.w3.org/2000/01/rdf-schema#label |
steroid hormone receptors
|
| gptkbp:inhibitedBy |
antagonists
|
| gptkbp:location |
gptkb:cytoplasm
cell nucleus |
| gptkbp:mechanismOfAction |
ligand-activated transcription factor
|
| gptkbp:memberOf |
nuclear receptor superfamily
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
endocrine disorders |
| gptkbp:regulates |
development
homeostasis metabolism immune response reproductive function |
| gptkbp:researchArea |
molecular biology
oncology endocrinology |
| gptkbp:structure |
DNA-binding domain
ligand-binding domain activation domain |
| gptkbp:target |
hormone therapy
anti-hormone drugs |
| gptkbp:bfsParent |
gptkb:Nuclear_receptor_superfamily
gptkb:Hsp90 |
| gptkbp:bfsLayer |
7
|