Aryl hydrocarbon receptor pathway
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
dioxins
polycyclic aromatic hydrocarbons |
| gptkbp:discoveredBy |
1976
|
| gptkbp:foundIn |
vertebrates
|
| https://www.w3.org/2000/01/rdf-schema#label |
Aryl hydrocarbon receptor pathway
|
| gptkbp:involves |
gptkb:cancer
gptkb:heat_shock_protein_90 autoimmune diseases ligand binding developmental toxicity DNA binding gene transcription regulation Aryl hydrocarbon receptor XAP2 protein XRE (xenobiotic response element) dimerization with ARNT p23 protein translocation to nucleus AIP (Aryl hydrocarbon receptor-interacting protein) ARNT (Aryl hydrocarbon receptor nuclear translocator) |
| gptkbp:modulatedBy |
endogenous ligands
exogenous ligands |
| gptkbp:regulates |
cell differentiation
cell proliferation immune response xenobiotic metabolism CYP1A1 gene expression |
| gptkbp:relatedTo |
toxicology
environmental health endocrine disruption |
| gptkbp:bfsParent |
gptkb:ARNT
|
| gptkbp:bfsLayer |
7
|