|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:HSP90B
gptkb:HSP90BETA
gptkb:HSPCB
gptkb:HSP_90-beta
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:conservedIn
|
eukaryotes
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
gptkb:Heat_shock_protein_HSP_90-beta
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000096384
3326
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:function
|
protein folding
cellular stress response
molecular chaperone
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5244
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSP90AB1
|
|
gptkbp:interactsWith
|
gptkb:FKBP51
gptkb:FKBP52
gptkb:STIP1
gptkb:HSP70
gptkb:AHA1
gptkb:CDC37
p23
|
|
gptkbp:length
|
724 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
gptkb:chromosome_6
|
|
gptkbp:molecularWeight
|
~83 kDa
|
|
gptkbp:OMIM
|
140572
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hsp90ab1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:heat_shock_protein_90_family
|
|
gptkbp:regulates
|
gptkb:HSP90_inhibitors
heat shock
cellular stress
|
|
gptkbp:significance
|
target for cancer therapy
biomarker for disease
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P08238
|
|
gptkbp:bfsParent
|
gptkb:HSP90
gptkb:Hsp90
|
|
gptkbp:bfsLayer
|
7
|