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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
|
Heat shock protein 90 family
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gptkbp:conservedIn
|
highly conserved
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gptkbp:firstDescribed
|
1970s
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gptkbp:foundIn
|
eukaryotes
|
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gptkbp:function
|
molecular chaperone
|
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gptkbp:GO_term
|
GO:0003755
|
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https://www.w3.org/2000/01/rdf-schema#label
|
HSP90 family
|
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gptkbp:inhibitedBy
|
gptkb:geldanamycin
gptkb:radicicol
|
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gptkbp:interactsWith
|
client proteins
co-chaperones
|
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gptkbp:involvedIn
|
protein folding
cellular stress response
|
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gptkbp:involves
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gptkb:cancer
infectious diseases
neurodegenerative diseases
|
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gptkbp:locale
|
gptkb:endoplasmic_reticulum
gptkb:cytoplasm
mitochondria
|
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gptkbp:member
|
gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
gptkb:TRAP1
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:orthologIn
|
gptkb:yeast
animals
plants
|
|
gptkbp:requires
|
cell viability
|
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gptkbp:role
|
signal transduction
protein degradation
cell cycle control
kinase stabilization
steroid receptor maturation
|
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gptkbp:structure
|
C-terminal domain
ATPase domain
middle domain
|
|
gptkbp:target
|
anticancer drugs
|
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gptkbp:bfsParent
|
gptkb:GRP94
|
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gptkbp:bfsLayer
|
8
|