glycogen synthase kinase-3 beta (GSK-3β)

URI: https://gptkb.org/entity/glycogen_synthase_kinase-3_beta_(GSK-3β)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:GSK3B
gptkb:GSK-3_beta
glycogen synthase kinase 3 beta
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
gptkbp:discoveredBy 1990
gptkbp:enzymeCommissionNumber EC 2.7.11.26
gptkbp:function regulation of apoptosis
regulation of cell proliferation
regulation of Wnt signaling pathway
regulation of glycogen metabolism
phosphorylation of serine/threonine residues
gptkbp:gene gptkb:GSK3B
https://www.w3.org/2000/01/rdf-schema#label glycogen synthase kinase-3 beta (GSK-3β)
gptkbp:inhibitedBy gptkb:insulin
lithium
Akt (protein kinase B)
gptkbp:locatedOnChromosome chromosome 3q13.33
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:member serine/threonine protein kinases
gptkbp:molecularWeight 47 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Gsk3b
gptkbp:PDB gptkb:1Q4L
4ACD
gptkbp:phosphorylates Ser9
Tyr216
gptkbp:regulates gptkb:glycogen_synthase
gptkb:Wnt_signaling
gptkb:beta-catenin
apoptosis
gene expression
inflammation
cell cycle
microtubule dynamics
neuronal development
insulin signaling
NF-κB signaling
CREB activity
gptkbp:substrate gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
gptkbp:UniProtID gptkb:P49841
gptkbp:bfsParent gptkb:Tideglusib
gptkbp:bfsLayer 7