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gptkbp:instanceOf
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gptkb:gene
|
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gptkbp:alternativeName
|
CYPXIX
aromatase cytochrome P450
estrogen synthetase
|
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gptkbp:associatedWith
|
aromatase deficiency
estrogen excess
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gptkbp:encodes
|
gptkb:aromatase
|
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gptkbp:Entrez_Gene_ID
|
1588
ENSG00000137869
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gptkbp:enzymeCommissionNumber
|
1.14.14.14
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gptkbp:expressedIn
|
gptkb:placenta
gptkb:testis
brain
adipose tissue
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gptkbp:function
|
catalyzes conversion of androgens to estrogens
|
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gptkbp:geneType
|
protein-coding
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gptkbp:HGNC_ID
|
2594
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP19A1
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q21.2
|
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gptkbp:mutationAssociatedWith
|
can cause disorders of sex development
|
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gptkbp:OMIM
|
107910
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologInMouse
|
Cyp19a1
|
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gptkbp:proteinFamily
|
gptkb:cytochrome_P450
|
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gptkbp:regulates
|
regulated by gonadotropins
regulated by steroid hormones
|
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gptkbp:significance
|
target for aromatase inhibitors in breast cancer therapy
|
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gptkbp:UniProtID
|
P11511
|
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gptkbp:bfsParent
|
gptkb:CYP19_family
gptkb:CYP_family
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gptkbp:bfsLayer
|
5
|