Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:Ras
gptkb:receptor_tyrosine_kinases |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2)
|
| gptkbp:composedOf |
p110 catalytic subunit
p85 regulatory subunit |
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
gptkb:PIK3CB_gene gptkb:PIK3CD_gene |
| gptkbp:foundIn |
mammals
|
| https://www.w3.org/2000/01/rdf-schema#label |
class IA PI3K
|
| gptkbp:inhibitedBy |
gptkb:Wortmannin
gptkb:LY294002 |
| gptkbp:involvedIn |
phosphoinositide 3-kinase signaling pathway
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
immunodeficiency |
| gptkbp:produces |
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
| gptkbp:role |
cell survival
metabolism cancer progression cell growth |
| gptkbp:subunit |
gptkb:PIK3CA_(p110α)
gptkb:PIK3CB_(p110β) gptkb:PIK3R2_(p85β) gptkb:PIK3R3_(p55γ) PIK3CD (p110δ) PIK3R1 (p85α) |
| gptkbp:bfsParent |
gptkb:p110δ
gptkb:PI3K_delta |
| gptkbp:bfsLayer |
6
|