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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alias
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gptkb:MYC_protein
v-myc avian myelocytomatosis viral oncogene homolog
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gptkbp:associatedWith
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gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
hepatocellular carcinoma
|
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gptkbp:binds
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E-box DNA sequences
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gptkbp:degradedBy
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gptkb:ubiquitin-proteasome_pathway
|
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gptkbp:encodedBy
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gptkb:MYC_gene
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gptkbp:Entrez_Gene_ID
|
4609
|
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gptkbp:firstDescribed
|
1979
|
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gptkbp:formsHeterodimerWith
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gptkb:MAX_protein
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-MYC protein
|
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gptkbp:interactsWith
|
gptkb:MAX_protein
gptkb:MAD_protein
|
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gptkbp:involvedIn
|
oncogenesis
|
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gptkbp:locale
|
gptkb:nucleus
|
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gptkbp:locatedOnChromosome
|
gptkb:8q24
|
|
gptkbp:molecularWeight
|
~49 kDa
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:overexpressedIn
|
many cancers
|
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gptkbp:PDB
|
1NKP
|
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gptkbp:phosphorylates
|
gptkb:Serine_62
gptkb:Threonine_58
|
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
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gptkbp:regulates
|
apoptosis
differentiation
metabolism
cell cycle progression
cell growth
DNA replication
cellular transformation
ribosome biogenesis
|
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gptkbp:requires
|
embryonic development
stem cell maintenance
|
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gptkbp:structure
|
basic helix-loop-helix leucine zipper (bHLH-LZ) domain
|
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gptkbp:target
|
gptkb:siRNA
antisense oligonucleotides
small molecule inhibitors
|
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gptkbp:UniProtID
|
P01106
|
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gptkbp:bfsParent
|
gptkb:POU5F1_gene
|
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gptkbp:bfsLayer
|
7
|