anaplastic lymphoma kinase (ALK)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:ALK_tyrosine_kinase_receptor gptkb:CD246
gptkbp:associatedWith	gptkb:anaplastic_large_cell_lymphoma gptkb:neuroblastoma gptkb:non-small_cell_lung_cancer
gptkbp:discoveredBy	gptkb:Steven_A._Morris
gptkbp:discoveredIn	1994
gptkbp:encodedBy	gptkb:ALK_gene
gptkbp:Entrez_Gene_ID	238
gptkbp:expressedIn	brain neurons
gptkbp:function	gptkb:receptor_tyrosine_kinase cell growth regulation neuronal development
gptkbp:gene	gptkb:ALK
gptkbp:HGNC_ID	427
https://www.w3.org/2000/01/rdf-schema#label	anaplastic lymphoma kinase (ALK)
gptkbp:inhibitedBy	gptkb:alectinib gptkb:brigatinib gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib
gptkbp:locatedOnChromosome	chromosome 2 2p23
gptkbp:molecularWeight	162 kDa
gptkbp:mutationAssociatedWith	gptkb:gene gptkb:C1156Y gptkb:EML4-ALK_fusion gptkb:NPM-ALK_fusion gptkb:R1275Q gptkb:S1206Y point mutation F1174L G1202R G1269A L1196M
gptkbp:OMIM	105590
gptkbp:PDB	gptkb:3LCS
gptkbp:phosphorylates	Y1278 Y1282 Y1283
gptkbp:proteinFamily	gptkb:insulin_receptor_subfamily
gptkbp:targetOfDrug	gptkb:alectinib gptkb:brigatinib gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib
gptkbp:UniProtID	gptkb:Q9UM73
gptkbp:bfsParent	gptkb:ceritinib
gptkbp:bfsLayer	6