|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
neurogenesis
stem cell maintenance
tissue regeneration
bone development
|
|
gptkbp:binds
|
gptkb:Frizzled_receptors
gptkb:LRP5/6_co-receptors
|
|
gptkbp:discoveredBy
|
gptkb:Harold_Varmus
gptkb:Rik_Derynck
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell migration
regulation of embryonic development
cell-to-cell communication
regulation of cell polarity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Wnt
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:modulatedBy
|
gptkb:Axin
gptkb:GSK3β
gptkb:R-spondin
gptkb:APC
gptkb:β-catenin
gptkb:DKK1
gptkb:WIF1
gptkb:sFRP
gptkb:Notum
Porcupine
|
|
gptkbp:nameOrigin
|
combination of 'Wingless' and 'Int-1'
|
|
gptkbp:pathway
|
canonical Wnt pathway
non-canonical Wnt pathway
|
|
gptkbp:proteinFamily
|
gptkb:WNT1
gptkb:WNT10A
gptkb:WNT10B
gptkb:WNT11
gptkb:WNT16
gptkb:WNT2
gptkb:WNT3
gptkb:WNT4
gptkb:WNT5A
gptkb:WNT5B
gptkb:WNT6
gptkb:WNT7A
gptkb:WNT7B
gptkb:WNT8A
gptkb:WNT8B
gptkb:WNT9A
gptkb:WNT9B
|
|
gptkbp:relatedTo
|
gptkb:cancer
developmental biology
oncogenesis
|
|
gptkbp:bfsParent
|
gptkb:Wingless-related_integration_site
|
|
gptkbp:bfsLayer
|
7
|