|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gene transcription
|
|
gptkbp:alsoKnownAs
|
gptkb:Wnt_pathway
|
|
gptkbp:canonical_pathway
|
β-catenin dependent
|
|
gptkbp:discoveredBy
|
gptkb:Rik_Derynck
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:bone
colorectal cancer
|
|
gptkbp:firstDescribed
|
gptkb:Drosophila_melanogaster
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WNT signaling
|
|
gptkbp:importantFor
|
angiogenesis
immune response
bone formation
neurogenesis
organogenesis
tissue regeneration
cardiac development
axis formation
hair follicle development
limb development
synapse formation
|
|
gptkbp:inhibitedBy
|
gptkb:sFRP_proteins
gptkb:WIF-1
gptkb:DKK1
|
|
gptkbp:involves
|
gptkb:APC_protein
gptkb:Axin
gptkb:Dishevelled_proteins
gptkb:Frizzled_receptors
gptkb:GSK-3β
gptkb:TCF/LEF_transcription_factors
gptkb:β-catenin
gptkb:LRP5/6_co-receptors
phosphorylation
ubiquitination
proteasomal degradation
WNT proteins
secreted glycoproteins
|
|
gptkbp:non-canonical_pathway
|
β-catenin independent
|
|
gptkbp:pathway
|
canonical WNT pathway
non-canonical WNT pathway
|
|
gptkbp:regulates
|
cell proliferation
embryonic development
cell migration
cell fate determination
stem cell maintenance
cell polarity
|
|
gptkbp:bfsParent
|
gptkb:WNT3_gene
|
|
gptkbp:bfsLayer
|
8
|