|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:VEGFA
vascular permeability factor
|
|
gptkbp:alternativeSplicing
|
multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
age-related macular degeneration
diabetic retinopathy
pre-eclampsia
|
|
gptkbp:biologicalProcess
|
angiogenesis
endothelial cell proliferation
growth factor activity
vasculogenesis
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodes
|
VEGF protein
|
|
gptkbp:Entrez_Gene_ID
|
7422
ENSG00000112715
|
|
gptkbp:expressedIn
|
endothelial cells
tumor cells
|
|
gptkbp:fullName
|
vascular endothelial growth factor gene
|
|
gptkbp:function
|
increases vascular permeability
stimulates angiogenesis
regulates blood vessel formation
|
|
gptkbp:HGNC_ID
|
HGNC:12680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
gptkb:chromosome_6
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
cancer progression
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Vegfa
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:product
|
gptkb:VEGF-A
|
|
gptkbp:proteinFamily
|
gptkb:VEGF_family
|
|
gptkbp:recipient
|
gptkb:VEGFR1
gptkb:VEGFR2
gptkb:VEGFR3
|
|
gptkbp:regulates
|
gptkb:hypoxia
|
|
gptkbp:target
|
anti-VEGF therapy
|
|
gptkbp:targetOfDrug
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
gptkb:sorafenib
gptkb:sunitinib
gptkb:pegaptanib
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:bfsParent
|
gptkb:chromosome_6_(human)
gptkb:hypoxia_response_elements_(HREs)
|
|
gptkbp:bfsLayer
|
7
|