Vascular permeability factor

URI: https://gptkb.org/entity/Vascular_permeability_factor
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:VEGF
gptkb:VPF
gptkbp:alsoKnownAs gptkb:vascular_endothelial_growth_factor
gptkbp:biologicalProcess embryonic development
wound healing
inflammation
vasculogenesis
gptkbp:discoveredBy Harold F. Dvorak
gptkbp:discoveredIn 1983
gptkbp:expressedIn gptkb:keratinocytes
macrophages
endothelial cells
tumor cells
smooth muscle cells
renal mesangial cells
gptkbp:family gptkb:VEGF_family
gptkbp:function increases vascular permeability
stimulates angiogenesis
gptkbp:gene gptkb:VEGFA
gptkbp:hasIsoform VEGF-A121
VEGF-A165
VEGF-A189
VEGF-A206
https://www.w3.org/2000/01/rdf-schema#label Vascular permeability factor
gptkbp:inhibitedBy corticosteroids
anti-VEGF antibodies
gptkbp:locatedOnChromosome chromosome 6p21.1 (human)
gptkbp:molecularWeight ~45 kDa (for VEGF-A165 isoform)
gptkbp:producedBy various cell types including macrophages and tumor cells
gptkbp:promotion gptkb:hypoxia
cytokines
growth factors
gptkbp:recipient gptkb:VEGFR-1
gptkb:VEGFR-2
gptkbp:role gptkb:cancer
psoriasis
age-related macular degeneration
diabetic retinopathy
rheumatoid arthritis
pre-eclampsia
gptkbp:structure gptkb:protein
gptkbp:target gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
anti-angiogenic therapies
gptkbp:bfsParent gptkb:VEGFA
gptkbp:bfsLayer 6