|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Vascular permeability factor (VPF)
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:VEGF-B
gptkb:PlGF
gptkb:VEGF-C
gptkb:VEGF-D
|
|
gptkbp:biologicalProcess
|
wound healing
tumor growth
vasculogenesis
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:VEGFA_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000112715
|
|
gptkbp:family
|
gptkb:VEGF_family
|
|
gptkbp:fullName
|
gptkb:Vascular_Endothelial_Growth_Factor_A
|
|
gptkbp:function
|
increases vascular permeability
promotes endothelial cell growth
stimulates angiogenesis
|
|
gptkbp:GO_term
|
GO:0038084
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF-A protein
|
|
gptkbp:inducedBy
|
gptkb:hypoxia
growth factors
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:molecularWeight
|
~27 kDa (monomer)
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1VPF
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:NRP1
gptkb:VEGFR-1
gptkb:VEGFR-2
|
|
gptkbp:RefSeq
|
NP_001020537.2
|
|
gptkbp:significance
|
implicated in age-related macular degeneration
implicated in diabetic retinopathy
target for anti-angiogenic cancer therapy
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:targetOfDrug
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:tissue_specificity
|
widely expressed in many tissues
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:bfsParent
|
gptkb:VEGFA
|
|
gptkbp:bfsLayer
|
6
|